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Ronald S. Duman

 

Neuroscience; Pharmacology & Molecular Medicine

Professor of Psychiatry and Pharmacology

Director, Division of Molecular Psychiatry and Abraham Ribicoff Research Facilities

Education

Ph.D. University of Texas 1984

Research Interests

Studies in Dr. Duman’s laboratory are focused on identifying the molecular and cellular adaptations that underlie the actions of antidepressant drugs and stress. This includes adaptations of receptors, signal transduction proteins, gene transcription factors, neurotrophic factors, and regulation of adult neurogenesis. Preclinical and clinical studies support the hypothesis that neuronal atrophy and cell loss in response to stress contribute to mood disorders. Conversely, the therapeutic action of antidepressants may occur in part via blocking or reversing these effects of stress. A variety of molecular approaches combined with cellular and behavioral studies are conducted to elucidate the basis of complex behavioral abnormalities.

Links

• Duman Homepage

 

Recent Publications

• Warner-Schmidt, J.L. and Duman, R.S. (2007). Vascular endothelial growth factor is an essential mediator of the neurogenic and behavioral actions of antidepressants. Proc. Nat. Acad. Sci. (USA) 104:4647-4652.
• Newton, S.S., Girgenti, M.J., Collier, E.F., and Duman, R.S. (2006). Electroconvulsive seizure increases adult hippocampal angiogenesis in rats. Eur. J. Neurosci. 24:819-828.

Contact

E-mail
ronald.duman@yale.edu