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Warren Shlomchik

 

Immunology

Associate Professor of Internal Medicine and Immunobiology

Education

B.A. Harvard University 1984
M.D. University of Pennsylvania 1989

Research Interests

Dr. Warren Shlomchik’s lab studies Graft-vs.-Host Disease (GVHD) and Graft-vs.-Leukemia (GVL) in murine models of allogeneic stem cell transplantation. T cells that accompany stem cell grafts are key players in alloSCT. They can mediate a potent anti-neoplastic effect by recognizing host malignant cells as non-self. They are also critical for reconstituting anti-infectious T cell immunity. However, as currently practiced, alloSCT has two key drawbacks. First, donor T cells can mount a global attack on normal host tissues such as skin, liver, and intestines in a process called Graft-vs.-Host Disease (GVHD). Because of GVHD, all patients receive some type of immunosuppression which reduces GVHD, but at the cost of decreased immune reconstitution and GVL. Second, many neoplasms such as blast crisis CML are resistant to GVL for reasons yet to be elucidated. Dr. Shlomchik’s lab uses murine models of GVHD and GVL to understand basic principles of antigen presentation, T cell activation, and T cell effector function with a goal of developing new therapeutic approaches to overcome these obstacles.

Recent Publications

• Shlomchik, W.D. (2007). Graft-versus-host disease. Nat. Rev. Immunol. 7:340-52.
• Anderson, B.E., Shlomchik, W.D., and Shlomchik, M.J. (2006). Recipient gammadelta T cells in graft-versus-host disease. Blood 107(9):3808-9.

Contact

E-mail
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