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Stephen G. Waxman

 

Neuroscience; Pharmacology & Molecular Medicine

Professor and Chairman of Neurology
Professor of Pharmacology and Neurobiology

Education

A.B. Harvard University 1967
Ph.D. Albert Einstein College of Medicine 1970
M.D. Albert Einstein College of Medicine 1972

Research Interests

My research program focuses on the application of molecular techniques to the study of neurological diseases, especially spinal cord injury, multiple sclerosis, and neuropathic pain. We are interested in understanding the molecular basis for functional recovery after CNS injury. Our studies on ion channels in impulse conduction in normal, demyelinated, and regenerating nerve fibers use molecular biological, immunoultrastructural, pharmacological, and patch-clamp techniques. We are also investigating the modification of conduction properties by pharmacologically altering ion channel characteristics, an approach that has led to clinical studies in multiple sclerosis and spinal cord injury. Using familial erythromelalgia, a human pain syndrome as a model system, we are studying the role of sodium channels in the regulation of excitability of pain-signaling sensory neurons. We hope that our work will lead to new therapies not only for erythromelalgia but also for multiple sclerosis, spinal cord injury, and related disorders.

Links

• Waxman Homepage

Recent Publications

• Waxman, S.G. (2006). Axonal conduction and injury in multiple sclerosis: the role of sodium channels. Nat. Rev. Neurosci. 5:932-942.
• Waxman. S.G. and Hains, B.C. (2006). Fire and phantoms after spinal cord injury: sodium channels and central pain. Trends Neurosci. 29:207-215.

Contact

E-mail
stephen.waxman@yale.edu