keith.choate@yale.edu

Boyer Center for Molecular Medicine
Lifton Laboratory, Room 149
295 Congress Avenue
New Haven, CT   06511
 

Education:

Canterbury School Valedictorian 1992
Stanford University   BS Biological Science with Honors, 1995
Yale University, MSTP Program, matriculated 1996
 

Research Interests:

Biochemical and molecular characterization of paracellin-1 mediated renal magnesium flux.

Research Experience:

1993-1996             Stanford University School of Medicine.  Khavari laboratory
1996-present        Yale University School of Medicine.  Lifton laboratory

Publications:

1. David B. Simon, Yin Lu, Keith A. Choate, Heino Velazquez, Essam Al-Sabban, Manuel Praga, Giorgio Casari,, Alberto Bettinelli, Giacomo Colussi, Juan Rodriguez-Soriano, David McCredie, David Milford, Sami Sanjad, and Richard P. LiftonParacellin-1, a Renal Tight Junction Protein Required for Paracellular Mg2+ Resorption Science 1999 July 2; 285: 103-106.

2. Deng H. Choate KA. Lin Q. Khavari PA. High-efficiency gene transfer and pharmacologic selection of genetically
engineered human keratinocytes. Biotechniques. 25(2):274-80, 1998 Aug.

3. Choate KA. Williams ML. Elias PM. Khavari PA. Transglutaminase 1 expression in a patient with features of
harlequin ichthyosis: case report. Journal of the American Academy of Dermatology. 38(2 Pt 2):325-9,
1998 Feb.

4. Choate KA. Williams ML. Khavari PA. Abnormal transglutaminase 1 expression pattern in a subset of patients with
erythrodermic autosomal recessive ichthyosis. Journal of Investigative Dermatology. 110(1):8-12, 1998 Jan.

5. Choate KA. Khavari PA. Direct cutaneous gene delivery in a human genetic skin disease. Human Gene Therapy.
8(14):1659-65, 1997 Sep 20.

6. Freiberg RA. Choate KA. Deng H. Alperin ES. Shapiro LJ. Khavari PA. A model of corrective gene transfer in
X-linked ichthyosis. Human Molecular Genetics. 6(6):927-33, 1997 Jun.

7. Choate KA. Khavari PA. Sustainability of keratinocyte gene transfer and cell survival in vivo. Human Gene
Therapy. 8(8):895-901, 1997 May 20.

8. Freiberg RA. Spencer DM. Choate KA. Duh HJ. Schreiber SL. Crabtree GR. Khavari PA. Fas signal transduction
triggers either proliferation or apoptosis in human fibroblasts. Journal of Investigative Dermatology. 108(2):215-9, 1997
Feb.

9. Choate KA. Kinsella TM. Williams ML. Nolan GP. Khavari PA. Transglutaminase 1 delivery to lamellar ichthyosis
keratinocytes. Human Gene Therapy. 7(18):2247-53, 1996 Dec 1.

10. Freiberg RA. Spencer DM. Choate KA. Peng PD. Schreiber SL. Crabtree GR. Khavari PA. Specific triggering of the
Fas signal transduction pathway in normal human keratinocytes. Journal of Biological Chemistry. 271(49):31666-9, 1996
Dec

11. Choate KA. Medalie DA. Morgan JR. Khavari PA. Corrective gene transfer in the human skin disorder lamellar
ichthyosis. Nature Medicine. 2(11):1263-7, 1996  cover

    Renal section stained with anti PCLN-1 (green)
    and anti THP (red) demonstrating localization of
    PCLN-1 to the tight junctions of the thick ascending
    limb of Henle