Recent Scientific Articles Published by Our Staff
Alsobrook II, JP, Pauls DL: The genetics of Tourette Syndrome. Neurologic Clinics of North America, 15(2):381-393, 1997.
Alsobrook II, JP, Pauls, DL: Molecular approaches to child psychopathology. Human Biology 70(2):413-432, 1998.
Alsobrook II, JP, Leckman JF, Goodman W, Rasmussen SA, Pauls DL: Segregation analysis of obsessive-compulsive disorder using symptom-based factors. American Journal of Medical Genetics, Neuropsychiatric Genetics, 88(6):669-675, 1999.
Carter AS, Pauls DL, Leckman JF: The development of obsessionality: Continuities and discontinuities. In: Developmental Psychopatholohy, DV Cicchetti, DJ Cohen (Eds.). New York: John Wiley and Sons, pp., 609-632, 1995.
Chappell PB, Leckman JF, Goodman WK, Anderson GM, McDougle DJ, Riddle MA, Mcswiggan-Hardin MT, Walker DE, Scahill LD, Ort SI, Pauls DL, Cohen DJ, Price LH: CSF corticotropin releasing factor is elevated in Tourette's syndrome: Comparison to obsessive-compulsive disorder and normal controls. Biological Psychiatry, 39:776-783, 1996.
Chappell PB, Riddle MA, Scahill S, Lynch KA, Schultz R, Arnsten A, Leckman JF, Cohen DJ: Guanfacine treatment of comorbid Attention Deficit Hyperactivity Disorder and Tourette's syndrome: Preliminary clinical experience. Journal of the American Academy of Child and Adolescent Psychiatry, 34(9):1140-1146, 1995.
Cohen DJ, Leckman JF, Pauls D: Neuropsychiatric disorders of childhood: Tourette's syndrome as a model. Acta Paediatr Suppl 1997; 422:106-111
Cohen DJ, Leckman JF: Developmental Psychopathology and Neurobiology of Tourette's syndrome. Journal of the American Academy of Child and Adolescent Psychiatry, 33:2-15, 1994.
Cohen DJ, King RA, Leckman JF: Psychiatric implications of movement disorders on the individual and family. In MM Robertson, V Eapen (eds.), Movement and allied disorders in childhood. London: John Wiley and Sons, Inc, 1995.
Ding M, Robel L, James AJ, Leckman JF, Rubenstein JLR, Vaccarino FM: The Dlx2 homeobox gene controls the expression of microtubule associated protein 2 (MAP2) in primary cultures of developing basal ganglia. J Molecular Neurosci. 1997; 8:93-113.
Dykens EM, Leckman JF, Cassidy SB: Obsessions and compulsions in Prader-Willi Syndrome. Journal of Child Psychology and Psychiatry, in press.
Eapen V, Robertson MM, Alsobrook II, JP, Pauls DL: Obsessive compulsive symptoms in Gilles de la Tourette's syndrome and obsessive compulsive disorder: Differences by diagnosis and family history. American Journal of Medical Genetics, Neuropsychiatric Genetics, 74(4):432-438, 1997.
Evans DW, King RA, Leckman JF: Tourette Syndrome and Tic disorders. In EJ Mash, RA Barkley (eds.), Child Psychopathology, New York: Guilford Press, pp 436-454, 1996.
Evans DW, Leckman JF, Carter AS, Reznick JS, Pauls DL: Ritual, habit and perfectionism: The prevalence and development of compulsive-like behavior in young children. Child Development, in press.
Gelernter J, Pauls DL, Leckman JF, Kidd KK, Kurlan R: D2 dopamine receptor (DRD2) alleles do not influence severity of Tourette syndrome in four large kindreds. Archives of Neurology, 51:397-400, 1994.
Gelernter J, Rao PA, Pauls DL, Hamblin MW, Sibley DR, Kidd KK: Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with Tourette Syndrome. Genomics, 26:207-209, 1995.
Grice DE, Leckman JF, Pauls DL, Kurlan R, Kidd KK, Fong M, Pakstis A, Cohen DJ, Gelernter J: Linkage disequilibrium of an allele at the dopamine D4 receptor locus with Tourette's syndrome by TDT. American Journal of Human Genetics, in press
King RA, Scahill LD: Obsessive-compulsive disorder in children and adolescents. In MM Robertson, V Eapen (eds.), Movement and allied disorders in childhood. London: John Wiley and Sons, Inc, pp. 43-56, 1995.
Kirwin PD, Anderson GM, Chappell PB, Saberski L, Leckman JF, Geracioti TD, Heninger GR, Price LH, McDougle: Assessment of diurnal variation of cerebrospinal fluid tryptophan and 5-hydroxyindoleacetic acid concentrations in healthy human females. Life Sci 1997; 60:899-907.
Leckman JF, Mayes LC: Understanding developmental psychopathology: How useful are evolutionary perspectives. J Am Acad Child Adolesc Psychiatry, in press.
Leckman JF, Zhang H, Vitale A, Lahnin F, Lynch K, Bondi C, Kim Y-S, PetersonBS. Course of tic severity in Tourette's syndrome: The first two decades. Pediatrics 1998; 102:14-19.
Leckman JF: What genes confer vulnerability to Gilles de la Tourette's syndrome? Psychiatric Ann, 1997; 27:1-4.
Leckman JF: A Darwinian Perspective on ADHD. Commentary on, "Evolution and revolution in child psychiatry: ADHD as a disorder of adaptation," by Jensen PS, Mrazek D, Knapp PK, Steinberg L, Pfeffer C, Schowalter J, Shapiro T. J Am Acad Child Adol Psychiatry 1997; 36: 1672-1679.
Leckman JF, Lombroso PJ: Why should a child and adolescent psychiatrist care about genetics and neuroscience? J Am Acad Child Adol Psychiatry 1998; 37: 115.
Leckman JF, Grice DE, Boardman J, Zhang H, Vitale A, Bondi C, Alsobrook J, Peterson BS, Cohen DJ, Rasmussen SA, Goodman WK, McDougle CJ, Pauls DL: Symptoms of obsessive compulsive disorder. Am J Psychiatry, 1997; 154:911-917.
Leckman JF, Cohen DJ: Tic disorders. In M Lewis (ed), Child and Asolescent Psychiatry: A Comprehensive Textbook, Second Edition, Baltimore: Williams and Wilkins, Chapter 57, pp. 622-629, 1996.
Leckman JF, Goodman WK, Anderson GM, Riddle MA, Chappell PB, McSwiggan-Hardin MT, Walker DE, Scahill LD, Ort SI, Pauls DL, Cohen DJ, Price LH: CSF biogenic amines in obsessive compulsive disorder and Tourette's syndrome. Neuropsychopharmacology, 12:73-86, 1995.
Leckman JF, Goodman WK, North WG, Chappell PB, Price LH, Pauls DL, Anderson GM, Riddle MA, McSwiggan-Hardin MT, McDougle CJ, Barr LC, Cohen DJ: Elevated levels of CSF oxytocin in obsessive compulsive disorder: Comparison with Tourette's syndrome and healthy controls. Archives of General Psychiatry, 51:782-783, 1994.
Leckman JF, Goodman WK, North WG, Chappell PB, Price LH, Pauls DL, Anderson GM, Riddle MA, McDougle CJ, Barr LC, Cohen DJ: The role of oxytocin in obsessive compulsive disorder and related normal behavior. Psychoneuroendocrinology, 19:742-758, 1994.
Leckman JF, Grice DE, Barr LC, deVries ALC, Martin C, Cohen DJ, Goodman WK, Rasmussen SA: Tic-related vs. non-tic related obsessive compulsive disorder. Anxiety, 1:208-215, 1995.
Leckman JF, Pauls DL, Cohen DJ: Tic Disorders. In: Bloom FE, Kupfer DJ, eds: Psychopharmacology: The Fourth Generation of Progress. New York: Raven Press, pp.. 1665- 1674, 1995.
Leckman JF, Peterson BS, Anderson GM, Arnsten A, Pauls DL, Cohen DJ: Pathogenesis of Tourette's Syndrome. Journal of Child Psychology and Psychiatry and Allied Disciplines, in press.
Leckman JF, Walker WK, Goodman WK, Pauls DL, Cohen DJ: "Just right" perceptions associated with compulsive behaviors in Tourette's syndrome. American Journal of Psychiatry, 151:675-680, 1994.
Lombroso PJ, Scahill LD, Chappell PB, Pauls DL, Cohen DJ, Leckman JF: Tourette syndrome: A multigenerational, neuropsychiatric disorder. In W Weiner, A Lang (eds.), Behavioral Neurology of Movement Disoders: Advances in Neurology, Volume 65. New York: Raven Press, pp. 305-318, 1995.
Lombroso PJ, Scahill LD, King RA, Lynch KA, Chappell PB, Peterson BS, McDougle CJ, Leckman JF. Risperidone treatment of children and adolescents with chronic tic disorders: A preliminary report. Journal of the American Academy of Child and Adolescent Psychiatry, 34(9), 1147-1152, 1995.
Malison RT, McDougle CJ, Van Dyke CH, Scahill LD, Baldwin RM, Seibyl JP, Price LH, Leckman JF: Beta-CIT SPECT imaging demonstrates increased striatal dopamine transporter binding in Tourette syndrome. American Journal of Psychiatry, 152:1359-1361, 1995.
Martin A, State MW, Koeing K, Schultz R, Dykens EM, Cassidy SB, Leckman JF : Clinical case conference: Prader-Willi syndrome. Am J Psychiatry, in press.
McDougle CJ, Barr LC, Goodman WK, Pelton GH, Aronson SC, Anand A, Price LH: Lack of efficacy of clozapine monotherapy in refractory obsessive-compulsive disorder. American Journal of Psychiatry, 152:1812-1814, 1995.
McDougle CJ, Fleischmann RL, Epperson CN, Wasylink S, Leckman JF, Price LH: Risperidone addition in fluvoxamine-refractory obsessive-compulsive disorder: A case series. Journal of Clinical Psychiatry, 56:526-528, 1995.
McDougle CJ, Goodman WK, Leckman JF, Lee NC, Heninger GR, Price LH: Haloperidol addition in fluvoxamine-refractory obsessive compulsive disorder: A double blind, placebo controlled study in patients with and without tics, Archives of General Psychiatry, 51:302-308, 1994.
McDougle CJ, Kresch LE, Goodman WT, Naylor ST, Volkmar FR, Cohen DJ, Price LH: A case controled study of repetitive thoughts and behaviors in adults with autistic disorder and obsessive-compulsive disorder. American Journal of Psychiatry, 152:772-777, 1995.
Mercadante MT, Campos MCR, Marques-Dias MJ, Miguel EC, Leckman JF: Vocal tics in Sydenham?s chorea. J Am Acad Child Adolesc Psychiatry 1997; 36:305.
Miguel EC, Baer L, Rauch SL, Coffey BJ, Savage CR, O'Sullivan RL, Philips K, Moretti C, Leckman JF, Jenike MA: Repetitive motor behaviors in obsessive-compulsive disorder and Tourette's syndrome: Phenomenological differences. Brit J Psychiatry 1997; 170:140-145
Pauls DL, Alsobrook II, JP: The inheritance of obsessive-compulsive disorder. Child and Adolescent Psychiatric Clinics of North America, 8(3):481-496, 1999.
Pauls DL, Alsobrook II, JP, Goodman W, Rasmussen S, Leckman JF: A family study of obsessive compulsive disorder. American Journal of Psychiatry, 152:76-84, 1995.
Pauls DL, Leckman JF, Cohen DJ: Evidence against a genetic relationship between Gilles de la Tourette's syndrome and anxiety, depression, panic and phobic disorders. British Journal of Psychiatry, 164:215-221, 1994.
Pauls DL, van de Wetering BJM: The genetics of tics and related disorders. In MM Robertson, V Eapen (eds.), Movement and allied disorders in childhood. London: John Wiley and Sons, Inc, Chapter 2, pp. 13-29, 1995
Peterson BS, Leckman JF: Temporal characterization of tics in Gilles de la Tourette's syndrome. Biol Psychiatry, in press.
Peterson BS, Zhang H, Bondi C, Anderson GM, Leckman JF: A double-blind, placebo-controlled, crossover trial of an antiandrogen in the treatment of Tourette's syndrome. J Clin Psychopharmacology 1998; 18:324-331..
Peterson BS, Skudlarski P, Anderson AW, Zhang H, Gatenby JC, Lacadie CM, Leckman JF, Gore JC: A functional magnetic resonance imaging study of tic suppression in Tourette syndrome. Arch Gen Psychiatry 1998; 55: 326-333.
Peterson BS: Neuroimaging in child and adolescent psychiatry. Journal of the American Academy of Child and Adolescent Psychiatry, 34:1560-1576, 1995.
Peterson BS, Bronen R, Duncan C: Three cases of Gilles de la Tourette's syndrome and obsessive-compulsive disorder associated with pediatric cerebral malignancies. Journal of Neurology, Neurosurgery and Psychiatry, in press.
Peterson BS, Leckman JF, Cohen DJ: Tourette's syndrome: A genetically predisposed, environmentally specified developmental psychopathology. In: Developmental Psychopathology, D Cicchetti, DJ Cohen (Eds.). New York: John Wiley and Sons, pp. 213-242, 1995.
Peterson BS, Leckman JF, Duncan J, Wetzels R, Riddle MA, Hardin MT, Cohen DJ: Corpus callosum morphology from MR Images in Tourette's syndrome. Psychiatry Research: Neuroimaging, 55:85-100, 1994.
Peterson BS, Tucker D: Neuroimaging in developmental neuropsychiatric disorders. In M Lewis (ed), Child and Asolescent Psychiatry: A Comprehensive Textbook, Second Edition, Baltimore: Williams and Wilkins, pp. 96-115, 1996.
Rasmusson AM, Anderson GA, Lynch KA, McSwiggan-Hardin M, Scahill LD, Mazure CM, Goodman WR, Price LH, Cohen DJ, Leckman JF: A preliminary study of tryptophan depletion on tics, obsessive-compulsive symptoms, and mood in Tourette's syndrome. Biol Psychiatry 1997; 41:117-121.
Riddle MA, Lynch KA, Scahill LD, Devries A, Cohen DJ, Leckman JF: Methylphenidate discontinuation and reinitiation during long term treatment of children with Tourette's syndrome and Attention Deficit Hyperactivity: A pilot study. Journal of the American Academy of Child and Adolescent Psychiatry, 5(3):205-214, 1995.
Santangelo SL, Pauls DL, Goldstein J, Faraone SV, Tsuang Mt, Leckman JF: Tourette's syndrome: What are the influences of gender and comorbid obsessive-compulsive disorder? Journal of the American Academy of Child and Adolescent Psychiatry, 33:795-804, 1994.
Scahill L, Riddle MA, King RA, Hardin MT, Rasmusson A, Makuch RW, Leckman JF Fluoxetine has no marked effect on tic symptoms in patients with Tourette's syndrome: a double-blind placebo-controlled study. J Child Adolesc Psychopharmacol 1997; 7:75-85
Scahill LD, Cohen DJ: Tics and Tourette's syndrome. In S Parker, S Zuckerman (eds.), Behavioral and Developmental Pediatrics: A Handbook for Primary Care, Boston: Little, Brown, p. 318-321, 1995.
Scahill LD, French P: Non-stimulant treatment of Attention Deficit Hyperactivity Disorder. Journal of Child and Adolescent Psychiatric Nursing, in press.
Scahill LD, Lynch KA: Pharmacologic treatment of children and adolescents with obsessive-compulsive disorder. Journal of Child and Adolescent Psychiatric Nursing, 8:36-40, 1995.
Scahill L, Riddle MA, McSwiggan-Hardin, Ort SI, King RA, Goodman WK, Leckman JF: Children?s Yale-Brown Obsessive Compulsive Scale: Reliability and validity. Am J Child Adolesc Psychiatry 1997; 36:844-852.
Scahill LD, Vitulano LA, Brenner E, Lynch KA, King RA: Behavioral therapy for children and adolescents with obsessive-compulsive disorder: A pilot study. Journal of Child and Adolescent Psychopharmacology, in press.
Schultz RT, Carter AS, Gladstone M, Scahill L, Leckman JF, Peterson BS, Zhang H, Cohen DJ, Pauls DL: Visual-motor integration, visuoperceptual and fine motor functioning in children with Tourette's syndrome, Neuropsychology 1998; 12: 134-145.
Schultz RT, Carter AS, Scahill LD, Cohen DJ, Leckman JF: Neuropsychology of TS, tic-related OCD and ADHD. In JF Leckman, DJ Cohen (eds.), Tourette's Syndrome and Related Forms of Obsessive-Compulsive and Attention Deficit Hyperactivity Disoder: Natural History, Genetics, Neurobiology and Treatment. New York: John Wiley & Sons, in press.
The Tourette Syndrome Association International Consortium for Genetics (Pauls DL, Leckman JF, Cohen DJ, Alsobrook II, JP, Hurst CR, members): A complete genome screen in sib-pairs affected with the Gilles de la Tourette syndrome. American Journal of Human Genetics, 65:1428-1436, 1999.
Tucker DM, Leckman JF, Scahill L, Epstein G, LaCamera R, Cardona L, Cohen P, Heidmann S, Goldstein J, Judge J, Snyder E, Bult A, Peterson BS, Lombroso P: A putative post-streptococcal case of obsessive-compulsive disorder with chronic tic disorder. Journal of the American Academy of Child and Adolescent Psychiatry, in press.
Walkup JT, Leckman JF, Price A, Hardin MT, Ort SI, Cohen DJ: The relationship between Obsessive-compulsive disorder and Tourette syndrome: A twin study. Psychopharmacology Bulletin, in press.
Yazgan Y, Wexler BE, Peterson BS, Leckman JF: Behavioral laterality in individuals with Gilles de la Tourette's syndrome and basal ganglia altrations: A preliminary report. Biological Psychiatry, 38:386-390, 1995.
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