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PHYSIOLOGICAL SYSTEMS
Fall
Semester
Course Listings:
Cellular
and Molecular Physiology: C&MP 550a
Biomedical Engineering:
BME 350a/550a
Molecular and Cellular Developmental Biology: MCDB 310a/550a
Web site for course information: http://classes.yale.edu
Classes: MWF 9:30-10:20 am
Location: 211 Mason Laboratory
(Discussion sections to be arranged)
Format: 36 Lectures, weekly quizzes,
two midterm examinations, final examination.
Graduate students meet for weekly
seminar on Wednesdays with Instructor in SHM B-145 at 5 to 6pm.
Instructor
in charge: Mark Saltzman, Ph.D.
Teaching Fellows & Discussion Section
Leaders:
Craig Gibson, Ethan Anderson, Michael Coggins Course
Description: We develop a foundation in human physiology and the principles
of feedback and homeostasis. The biophysical properties of cells, tissues and
organs are developed in context of the functions they perform. The concept of
homeostasis is considered at the cellular level and of the organism as a whole.
Our examination of cellular and membrane physiology provides a foundation for
understanding the neural control of effector systems. This background leads into
the physiology of skeletal muscle, smooth muscle in hollow organs and the heart
as a muscular pump. The regulation of cardiac output, blood flow, and vascular
exchange are integrated in light of exercise physiology. The respiratory system
is considered in light of the mechanical interactions between the lung and the
chest wall, gas exchange, and respiratory control of acid-base balance. The functional
organization of the kidney is explored with respect to how urine is formed and
its composition regulated, as well as how salt, fluid, and acid-base homeostasis
are regulated. The digestive system is developed in the context of energy balance
and temperature regulation, substrate and calcium metabolism, and its regulation
by hormones. Exercise physiology integrates energy production and its regulation
in the context of human performance. Exploring the biology of nerve cells, their
plasticity with learning, and how sensory information is coded throughout the
body leads into considering the special senses. The course concludes by considering
the integral link between physiological systems and biomedical engineering. Weekly
discussion sections provide a forum for in-depth exploration of questions and
concepts. Graduate students will, in addition, evaluate pertinent research topics
on a weekly basis through meeting with the instructor. Nature
and amount of work required:
Text: Human Physiology: From Cells
to Systems (5th Ed., 2004) by Lauralee Sherwood
Publisher: Brooks/Cole
(Thomson Learning)
Number of pages of reading per week: ~ 50 to 70;
indicated for each lecture.
Quizzes and Discussion Sections: (20%
of grade)
Midterm: Two midterms (each 20% of grade).
End of
term: Final examination (40% of grade).
Examination format: multiple
choice, true-false, & short answer.
Graduate students: weekly meeting
and report (20% of grade).
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