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Postdoctoral
Programs
Each
faculty laboratory is made up of some combination of postdoctoral fellows,
graduate students, and technical staff. Attracting highly qualified
postdoctoral collaborators is an important goal for each of the laboratories.
Three
kinds of support are available for postdoctoral fellows.
1.
NIH postdoctoral training grants
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The training grant "Transport
Processes in Biological Systems" is within the department of Physiology. There are four training positions
available every year. The purpose
of this training grant is twofold: 1) to enhance the research experience of individuals
with the Ph.D. degree in the area of cellular and molecular physiology
in order to prepare them for academic careers, 2) to provide clinically
trained fellows with adequate research training and experience to
enable them to carry out independent research in an academic setting.
The training objective is to educate four trainees annually in the
study of membrane function, more particularly of membrane channels,
transporters and pumps in a wide range of cell types. The research
expertise will be acquired through a program lasting one to three
years. Applicants for the postdoctoral training grant "Transport
Processes in Biological Systems" should address their request
to the Director of the training grant, Dr. Emile Boulpaep at the
following e-mail address: Emile.Boulpaep@yale.edu
Research
areas cover the molecular biology of membrane proteins, the physics
of their function, the basic mechanisms whereby ions, water and
organic molecules are transferred across biological membranes, the
regulation of membrane function, the involvement of membranes in
signal transduction, the biosynthesis, assembly, intracellular sorting,
targeting and insertion of membrane proteins, the role of membrane
processes in cell regulation, and the integrated function of cells
in epithelia. The biological membrane systems being studied include
isolated membrane proteins, cDNA clones that encode these proteins,
chimeric membrane proteins, mutant transport systems, cytoskeletal
elements associated with membrane proteins, specific monoclonal
antibodies, membrane fractions and membrane vesicles, liposomes,
bilayer lipid membranes, organelles within cells, isolated separated
single cells, cellular protoplasts, frog oocytes, symmetrical and
polarized cells in culture, epithelial cell sheets in culture, isolated
perfused renal tubules, renal tubule segments in situ, and isolated
epithelia. The methodologies which can be acquired though this program
cover molecular biological techniques, genetic recombination, in
vitro mutagenesis, transfection, protein isolation, protein chemistry,
expression of membrane proteins, reconstitution of membrane components,
electron microscopy and laser confocal microscopy, molecular probing
of membrane components, optical determinations of intracellular
composition, cell culturing, patch-clamping, intracellular voltage
and conductance measurements, intracellular ion activity measurements,
microdissection and microperfusion, as well as kinetic modeling.
2.
Faculty research grants
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Applicants
should address their request directly to the individual faculty
members of the Department of Cellular and Molecular Physiology.
3.
Individual postdoctoral fellowships
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These
include NIH National Research Service Awards, NSF postdoctoral fellowships,
and fellowships from a number of private or public foundations (e.g.
the American Heart Association).
The
stipend for postdoctoral fellows who have just received their Ph.D.
degree or M.D. degree is in accordance with the NIH postdoctoral stipend
scale, and is increased with the number of years of relevant experience.
In addition, the Department of Cellular and Molecular Physiology provides
coverage for health insurance.
The
postdoctoral training facilities
are primarily in the Department of Cellular and Molecular Physiology,
with additional space in the Departments of Genetics, Pathology, Internal
Medicine and Surgery. They include the well-equipped laboratories of
the principal investigators and core facilities for molecular biology,
cell culture, electron and laser confocal microscopy and an electronics
and machine shop.
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