Sigworth Laboratory
Yale
School of Medicine
Recent Publications
Sigworth FJ.
Classical
detection theory and the cryo-EM particle selection problem.
J Struct Biol. 2004 Jan-Feb;145(1-2):111-22.
Zhu Y,
Carragher B, Glaeser RM, Fellmann D, Bajaj C, Bern M, Mouche F, de Haas
F, Hall RJ, Kriegman DJ, Ludtke SJ, Mallick SP, Penczek PA, Roseman AM,
Sigworth FJ, Volkmann N, Potter CS.
Automatic
particle selection: results of a comparative study.
J Struct Biol. 2004 Jan-Feb;145(1-2):3-14.
Bhattacharjee
A, Joiner WJ, Wu M, Yang Y, Sigworth FJ, Kaczmarek LK.
Slick
(Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited
by ATP.
J Neurosci. 2003 Dec 17;23(37):11681-91.
Sigworth, F. J.
Life's transistors.
Nature 423:21-22, 2003.
Jiang, Q.-X., E. C. Thrower, D. W. Chester, B. E. Ehrlich and F. J. Sigworth.
Three-dimensional structure of
the type 1 inositol 1,4,5-trisphosphate receptor at 24 A resolution.
EMBO J. 21:3575-3581, 2002.
Klemic, K.G., Klemic, J.F., Reed, M.A. and Sigworth, F.J.
Micromolded PDMS planar electrode
allows patch clamp electrical recordings from cells.
Biosensors and Bioelectronics 17:597-604, 2002.
Venkataramanan, L. and F. J. Sigworth.
Applying hidden Markov models to the
analysis of single ion channel activity.
Biophys. J. 82: 1930-1942, 2002.
Sigworth F. J. and Klemic, K. G.
Patch clamp on a chip.
Biophys. J. 82:2831-2832,2002.
Zheng, J., L. Venkataramanan and F. J. Sigworth.
Hidden Markov Model Analysis of Intermediate
Gating Steps Associated with the Pore Gate of Shaker Potassium Channels.
J. Gen Physiol. 118:547-562, 2001.
Jiang, Q-X., D. W. Chester and F. J. Sigworth.
Spherical reconstruction. A method
for structure determination of membrane proteins from cryo-EM images.
J. Struct. Biol. 133:119-131. 2001.
Islas, L. D. and F. J. Sigworth.
Electrostatics and the gating pore
of Shaker potassium channels.
J. Gen. Physiol. 117:69-89, 2001.
Sigworth, F. J.
Potassium Channel Mechanics.
Neuron 32: 555-556, 2001.
Venkataramanan, L., R. Kuc and F. J. Sigworth.
Identification of hidden Markov models for ion channel currents, part
III.
Band-limited, sampled data. IEEE Transactions on Signal Processing 48:376-385,
2000
Islas, L. D. and F. J. Sigworth.
Voltage sensitivity and gating charge
in Shaker and Shab family potassium channels.
J Gen Physiol 114:723-742, 1999.
Baumgartner, W. and F. J. Sigworth.
Two-Microelectrode Voltage Clamp of
Xenopus Oocytes: Voltage Errors and Compensation for Local Current Flow.
Biophys J 77:1980-1991, 1999.
Yang, Y. and F. J. Sigworth.
Single-Channel Properties of IKs Potassium
Channels.
J. Gen. Physiol. 112: 665-678, 1998.
Sigworth, F. J.
A maximum-likelihood approach to
single-particle image refinement.
J. Struct. Biol. 122: 328-339, 1998.
Zheng, J. and F. J. Sigworth.
Intermediate conductances during deactivation
of heteromultimeric Shaker potassium channels.
J. Gen. Physiol. 112:457-474, 1998
Venkataramanan, L., R. Kuc and F. J. Sigworth.
Identification of hidden Markov models for ion channel currents containing
state-dependent noise.
IEEE Transactions on Signal Processing 46:1916-1929, 1998.
Venkataramanan, L., J. L. Walsh, R. Kuc and F. J. Sigworth.
Identification of hidden Markov models for ion channel currents containing
colored background noise.
IEEE Transactions on Signal Processing 46: 1901-1915, 1998.
Schoppa, N.E. and F. J. Sigworth.
Activation of Shaker potassium channels.
III. An activation gating model for wild-type and V2 mutant channels.
J. Gen. Physiol. 111: 313-342, 1998.
Schoppa, N.E. and F. J. Sigworth.
Activation of Shaker potassium channels.
II. Kinetics of the V2 mutant channel.
J. Gen. Physiol. 111: 295-312, 1998.
Schoppa, N.E. and F. J. Sigworth.
Activation of Shaker potassium channels.
I. Characterization of voltage-dependent transitions.
J. Gen. Physiol. 111:271-294, 1998.
Zheng, J. and F. J. Sigworth.
Selectivity changes during activation
of mutant Shaker potassium channels.
J. Gen. Physiol. 110: 101-117, 1997.
Yang, Y., Y. Yan and F. J. Sigworth.
How does the W434F mutation block current
in Shaker potassium channels?
J. Gen. Physiol. 109: 779-789, 1997.
Sigworth, F. J.
Voltage gating of ion channels.
Q. Rev. Biophys. 27:1-40, 1994.
Schoppa, N. E., K. McCormack, M. A. Tanouye and F. J. Sigworth.
The size of gating charge in wild-type
and mutant Shaker potassium channels.
Science 255: 1712-1715, 1992.
Last modified: June 21, 2004 ns.
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