Elizabeth B. Claus, Ph.D., M.D.
Professor,
Biostatistics
Director of Medical Research
Dr. Claus works in cancer epidemiology and statistical genetics with emphasis on the development of risk models for breast and ovarian cancer and tumors of the central nervous system (CNS). She is principal investigator of a study of 2000 female Connecticut residents examining the clinical (including mammographic density), genetic, and epidemiologic characteristics ofbreast carcinoma in-situ (BCIS), and following these women over time to better define their long-term outcomes, including those with mutations in two breast cancer susceptibility genes, BRCA1 and BRCA2. Dr. Claus is a neurosurgeon working in neuro-oncologic surgery, including the intra-operative use of magnetic resonance therapy and computer guided imagery for brain tumor removal, including glioma and metastatic lesions to the CNS, particularly metastatic breast cancer. She has recently received funding from NIH to commence the first national study of meningioma. This multi-state project will enroll over 3000 subjects to define genetic and environmental risk factors for meingioma as well as identify pedigrees with multiple family members affected with meningioma. Dr. Claus is also co-investigator in the GLIOGENE project, an international effort to identify genes associated with glioma.
Education
M.D., Yale University, 1994
Ph.D., Yale University, 1988
Courses Taught
BIS 505a Introduction to Statistical Thinking
BIS 631a Topics in Genetic Epidemiology
Current Research Projects
The Yale Breast Study; the Meningioma Consortium Project; the DCIS and BRCA1/2 Cohort Study; and GLIOGENE.
Selected Publications
Claus, E.B., Black, P.M., Bondy, M., Calvocoressi, L., Schildkraut, J., Wiemels, J., and Wrensch, M. Exogenous Hormones and Meningioma Risk: What Do We Tell Our Patients? Cancer, in press.
Malmer, B., Barnholtz-Sloan, J., Bernstein, J., Claus, E.B., Houlston, R., Jenkins, R., Johansen, C., Schildkraut, J., Lau, C., Sadetzki, S., Wrensch, M., and Bondy, M. Gliogene: An International Effort for Delineating the Underlying Causes of Familial Glioma. Cancer Epidemiology, Biomarkers, and Prevention, in press.
Claus, E.B., Petruzella, S., Carter, D., and Kasl, S. Quality of Life for Women Diagnosed with Breast Carcinoma in Situ. Journal of Clinical Oncology 4875-4881, 2006.
Claus, E.B. and Black, P.M. Survival Rates and Patterns of Care for Patients Diagnosed with Supratentorial Low-grade Gliomas: Data from the Surveillance, Epidemiology, and End Results (SEER) Program, 1973-2001. Cancer 106(6): 1358-1363, 2006.
Claus, E.B., Bondy, M.L., Schildkraut, J.M., Wiemels, J., Wrensch, M., and Black, P.M. Epidemiology of Intracranial Meningioma. Neurosurgery 57: 1088-1095, 2005.
Calvocoressi, L., Kasl, S.V., Lee, C.H., Stolar, M., Claus, E.B., and Jones, B.A. Applying Recursive Partitioning to a Prospective Study of Factors Associated with Adherence to Mammography Screening Guidelines. American Journal of Epidemiology 162(12): 1215-1224, 2005.
Claus, E.B., Petruzella, S., Matloff, E., and Carter, D. Prevalence of BRCA1 and BRCA2 Mutations in Women Diagnosed with Ductal Carcinoma In Situ. Journal American Medical Association 293(8): 964-969, 2005.
Claus, E.B., Horlacher, A., Hsu, L., Schwartz, R.B., Dello-Iacono, D., Talos, F., Jolesz, F.A., and Black, P.M. Survival Rates in Patients with Low-grade Patients after Intraoperative Magnetic Resonance Image Guidance. Cancer 103(6): 1227-1233, 2005.
For a further list of Dr. Claus’ publications, please see PubMed.
|
|
|
