Herbert Yu, M.D., Ph.D.
Associate Professor,
Division of Chronic Disease Epidemiology
Professor Yu's research interest is in molecular epidemiology of chronic diseases with focus on cancer etiology and tumor progression in relation to genetic variations, epigenetic changes, and gene-environment interaction. His recent work includes studies of molecular mechanisms underlying the connection of breast and endometrial cancers to lifestyle and energy balance, as well as DNA methylation in tumor suppressor genes and DNA repair genes and its role in aging and cancer prognosis. The effect of mitogenic growth factors on cancer development and the interplay of these growth factors with environment and lifestyle factors are also part of the research focus in Professor Yu's laboratory. Professor Yu also conducts clinical epidemiological studies to assess molecular and genetic markers for cancer diagnosis and prognosis. Professor Yu's laboratory serves as Molecular Epidemiology Shared Resource for the Yale Cancer Center.
Curriculum Vitae
Education
Ph.D., University of Toronto, 1996
M.Sc., University of Toronto, 1990
M.D. Shanghai Medical University, 1983
Awards and Honors
Wang Fellowship for International Study of Public Health, American Health Foundation
Young Investigator Award, American Association for Clinical Chemistry
Mitchell Scholarship in Cancer Research, University of Toronto
Young Investigator Award, Louisiana State University Medical Center
International Scholar Award Host in Breast Cancer Research, Avon Foundation and American Association for Cancer Research
Professional Services
National Institutes of Health (NIH)/National Cancer Institute (NCI) Special Emphasis Panel, 2004, 2006
NIH, NCI, Subcommittee, 2005-2006
NIH, National Institute of Environmental Health Sciences (NIEHS), P30ES000260-43, 2004-2005
NCI of Canada, C Panel, 2003-2005
NIH, NCI/National Institute on Aging (NIA) Special Emphasis Panel (ZCA1 GRB-H), 2003
Courses Taught
CDE 630a Molecular Epidemiology of Chronic Diseases
CDE 605b Gene Hunting – Research Methods to Identify Chronic Disease Genes
Current Research Projects
Role of Genetic and Lifestyle Interplay in Uterus Cancer; Molecular Characterization of the Insulin-like Growth Factor System in Breast Cancer and its Association with Progression; Case-control Study of Pancreatic Cancer Etiologic Factors; DNA Methylation, Aging, and Prostate Cancer Risk; Exercise Intervention in Breast Cancer Survivors; and Diabetes, Insulin, IGF-I and Cancer in Women.
Yale Affiliations
Yale Cancer Center
In the News
Yu Author on Study about New Procedure Cutting Recurrence of Aggressive Uterine Cancer
Yu Selected to Act as Mentor in Breast Cancer Research
Study to Analyze the Role of Mitogenic Growth Factors in Endometrial Cancer
Selected Publications
Beeghly, A., Katsaros, D., Chen, H., Fracchioli, S., Zhang, Y., Massobrio, M., Risch, H., Jones, B., and Yu, H. Glutathione S-transferase Polymorphisms and Ovarian Cancer Treatment and Survival. Gynecologic Oncology 100(2): 330-337, 2006.
Wiley, A., Katsaros, D., Fracchioli, S., and Yu, H. Methylation of the Insulin-like Growth Factor Binding Protein-3 Gene and Prognosis of Epithelial Ovarian Cancer. International Journal of Gynecological Cancer 16(1): 210-218, 2006.
Lu, L., Katsaros, D., Wiley, A., Rigault de la Longrais, I.A., Risch, H.A., Puopolo, M., and Yu, H. The Relationship of Insulin Growth Factor-II, Insulin Growth Factor Binding Protein-3 and Estrogen Receptor-a Expression to Disease Progression in Epithelial Ovarian Cancer. Clincal Cancer Research 12(4): 1208-1214, 2006.
Harris, T.G., Strickler, H.D., Yu, H., Pollak, M.N., Monrad, E.S., Travin, M.I., Xue, X., Rohan, T.E., and Kaplan, R.C. Specimen Processing Time and Measurement of Total Insulin-like Growth Factor-I (IGF-I), Free IGF-I, and IGF Binding Protein-3 (IGFBP-3). Growth Hormone & IGF Research 16(2): 86-92, 2006.
Wiley, A., Katsaros, D., Chen, H., Rigault de la Longrais, I.A., Beeghly, A., Puopolo, M., Singal, R., Zhang, Y., Amoako, A., Zelterman, D., and Yu, H. Aberrant Promoter Methylation of Multiple Genes in Malignant Ovarian Tumors and in Ovarian Tumors with Low Malignant Potential. Cancer 107(2): 299-308, 2006.
Wen, W., Gao, Y.T., Shu, X.O., Yu, H., Cai, Q., Smith, J.R., and Zheng, W. Insulin-like Growth Factor-I Gene Polymorphism and Breast Cancer Risk in Chinese Women. International Journal of Cancer 113(2): 307-311, 2005.
Kelly, M.G., O’Malley, D.M., Hui, P., McAlpine, J., Yu, H., Rutherford, T.J., Azodi, M., and Schwartz, P.E. Improved Survival in Surgical Stage I Patients with Uterine Papillary Serous Carcinoma (UPSC) Treated with Adjuvant Platinum-based Chemotherapy. Gynecologic Oncology 98(3): 353-359, 2005.
McClusky, D.R., Chu, Q., Yu, H., Debenedetti, A., Johnson, L.W., Meschonat, C., Turnage, R., McDonald, J.C., Abreo, F., and Li, B.D. A prospective trial on initiation factor 4E (eIF4E) overexpression and cancer recurrence in node-positive breast cancer. Annals of Surgery 242(4): 584-590, 2005.
For a further list of Dr. Yu’s publications, please see PubMed.
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