Clusters of industry: New Haven-area, Yale-affiliated biotechnology companies

Thirteen Yale-affiliated biotechnology companies are located in and around New Haven, and close to a dozen more businesses—the majority are expected to locate in the city—are now in development with assistance from Yale’s Office of Cooperative Research. The existing New Haven-based companies are clustered in several locations in the city center and in nearby Branford.

Publicly traded companies

Alexion Pharmaceuticals
Drug development for cardiovascular and autoimmune disorders, inflammation and cancer

CuraGen Corporation
Genomics-based drug discovery and development

Genaissance Pharmaceuticals
Population genomics and personalized medicine

Neurogen Corporation
Drug discovery and development for psychiatric, metabolic and inflammatory disorders

Vion Pharmaceuticals
Anti-cancer drug discovery, development and commercialization

Companies developed by the Office of Cooperative Research
Founder’s names in italics

Achillion Pharmaceuticals
Antiviral therapeutic discovery and development
Yung-Chi Cheng

Agilix
Agriculture gene discovery
Paul Lizardi

Cellular Genomics Inc.
Proteomics and functional genomics
Ira Mellman

L2 Diagnostics
Lyme disease diagnostics
Erol Fikrig, Joseph Craft and Richard Flavell

Molecular Staging Inc.
Molecular diagnostics based on rolling circle amplification technology
David Ward and Sherman Weissman

PhytoCeutica
Pharmaceutical development of traditional Chinese medicine
Yung-Chi Cheng

polyGenomics (now merged with Molecular Staging Inc.)
Disease-associated genetic mutations
Sherman Weissman and David Ward

RadioTracer
Development of novel brain imaging agents
Ronald Baldwin and Robert Innis

Recombinant Technologies
Production and distribution of novel research reagents
Pazhani Sundaram

Companies in development

GasNet
Anesthesiology Internet commerce Web site
Keith Ruskin and Charlotte Clark

TurboGenomics
Bioinformatic tools for genomics
Gregory Gardiner

Phoenix Drug Discovery
Disease-associated targets for drug development
Gregory Gardiner

UltraBiotics
Development of novel antibiotics
John Swartley

Axotech
Regeneration of CNS neurons
Stephen Strittmatter and Jeffery Kocsis

Rib-X Designs
Development of antibiotics and novel drug targets based on ribosome inhibition
Thomas Steitz and Peter Moore

Archemix
Molecular sensors for drug discovery
Ronald Breaker

Chemasense
Odorants to modify insect and pest behavior
John Carlson

Epigenix Inc.
Transgenic animals and functional genomics
Frank Ruddle and Adrian Hayday

Protometrix
Informatic tools for protein expression analysis
Michael Snyder and Sherman Weissman

VaxInnate
Vaccine cassettes for rapid development of novel vaccines
Ruslan Medzhitov and Richard Flavell



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Originally published in Yale Medicine, Fall 2000/Winter 2001.
Copyright © 2000-2001 Yale University School of Medicine. All rights reserved.