Publications

Selected Publications

• Green EA, Choi Y, Flavell RA. Pancreatic lymph node-derived CD4+CD25+ Treg cells; highly potent regulators of diabetes that require TRANCE-RANK signals. Immunity 16:183-191 (2002).
• Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double stranded RNA by Toll-like receptor 3. Nature 413:732-738 (2001).
• Lu B, Yu H, Chow C-w, Li B, Zheng W-p, Davis RJ, Flavell RA. GADD45gamma mediates the requirement of the p38 and JNK MAP kinase pathways and cytokine production in effector Th1 cells. Immunity 14:583-590 (2001).
• Dong C, Yang DD, Tournier C, Whitmarsh AJ, Xu J, Davis RJ, Flavell RA. JNK is required for effector T cell function but not for T cell activation. Nature 405:91-94 (2000).
• Lee GR, Fields PE, Flavell RA. Regulation of IL4 gene expression by distal regulatory elements and GATA-3 at the chromatin level. Immunity 14:447-459 (2001).
• Zheng TS, Hunot S, Kuida K, Momoi T, Srinivasan A, Nicholson DW, Lazebnik Y, Flavell RA. Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation. Nature Medicine 6:1241-1247 (2000).
• Kobayashi KS, Chamaillard M, Ogura Y, Henegariu O, Inohara N, Nuñez G, Flavell RA. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307:731-734 (2005).
• Spilianakis CG, Flavell RA: Long range intrachromosomal interactions in the Th2 cytokine locus. Nat. Immunol. 5:1017-1027 (2004).
• Spilianakis CG, Laliota M, Town T, Lee GR, Flavell RA. An interchromosomal association between two alternatively expressed loci, IFN-g and the TH2 cytokines in the CD4 T cell nucleus. Nature (in press) (2005). (Published online 05/01/05.)
• Gorelik L, Flavell, RA. Immune mediated eradication of tumors through the blockade of TGF-b signaling in T cells. Nat. Med. 7:1118-1122 (2001).
• Lee GR, Fields PE, Griffin TJ, IV, Flavell RA. Regulation of the Th2 cytokine locus by a locus control region. Immunity 19:145-153 (2003).
• Wan YY, Flavell RA. Identifying Foxp3 expressing suppressor T cells with a bi-cistronic reporter. Proc. Natl. Acad. Sci. USA 102:5126-5131 (2005). Published online 03/28/05.
• Amsen D, Blander JM, Lee GR, Tanigaki K, Honjo T, Flavell RA. Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell, 117: 515-526, 2004.
• Zhang Y, Blattman JN, Kennedy NJ, Duong J, Nguyen T, Wang Y, Davis RJ, Greenberg PD, Flavell RA, Dong, C.
  Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5. Nature, 430: 793-797, 2004.