Publications

Selected Publications

• Kopp, E. and Ghosh, S.  Inhibition of NF-kB by sodium salicylate and aspirin, Science 265, 956-959 (1994)
• Thompson, J.E., Phillips, R.J., Erdjument-Bromage, H., Tempst, P., and Ghosh, S.  IkB-ß regulates the persistent response in a biphasic activation of NFk-B, Cell 80, 573-582 (1995)
• Ghosh, G., Van Duyne, G., Ghosh, S., and Sigler, P.B. Structure of NF-kB p50 homodimer bound to a kB Site, Nature 373, 303-310 (1995)
• Beg, A.A., Sha, W.C., Bronson, R.T., Ghosh, S., and Baltimore, D. Embyonic lethality and liver degeneration in mice lacking the RelA component of NF-kB, Nature 376, 167-170 (1995)
• Zhong, H., SuYang, H., Erdjument-Bromage, H., Tempst, P., Ghosh, S. The transcriptional activity of NF-kB is regulated by IkB-associated PKAc subunit through a cyclic AMP independent mechanism, Cell 89, 413-424 (1997)
• Zhong, H., Voll, R. E. and Ghosh, S. Phosphorylation of NF-kB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the co-activator CBP/p300, Molecular Cell 1, 661-671 (1998)
•  Medzhitov, R., Kopp, E.B., Ghosh, S. and Janeway, C.A. MyD88 is a common intermediate in the IL-1 and Toll signal transduction pathways, Molecular Cell 2, 253-258 (1998)
•  Kopp, E., Medzhitov, R., Carothers, J., Xiao, C., Douglas, I., Janeway, C. A. and Ghosh, S. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway, Genes & Development 13, 2059-2071 (1999)
• Fenwick, C., Na, S-Y., Voll, R. E., Zhong, H., S-Y. Im, Lee, J. W. and Ghosh, S.  A sub-class of Ras proteins that regulate the degradation of IkB. Science 287, 869-873 (2000)
• Li, B., Yu, H., Zheng, W., Voll, R., Na, S., Roberts, A., Williams, D. A., Davis, R. J., Ghosh, S. and Flavell, R. A. Role of the guanosine triposphatase Rac2 in T helper 1 cell differentiation. Science 288, 2219-2222 (2000)
•  Voll, R.E., Jimi, E., Phillips, R.J., Barber, D.F., Rincon. M., Hayday, A.C., Flavell, R.A., and Ghosh. S.  NFk-B Activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development.  Immunity 13, 677-689 (2000)
• May, M. J., D’Acquisto, F., Madge, L. A., Gloeckner, J., Pober, J. S. and Ghosh, S.  Selective inhibition of NFk-B activation by a peptide that blocks the interaction of NEMO with the IkB kinase complex.  Science 289,1550-1554 (2000)
• Zhong, H., May, M. J., Jimi, E. and Ghosh, S.  Phosphorylation of nuclear NF-kB governs its association with either HDAC-1 or CBP/p300: a mechanism for regulating the transcriptional activity of NF-kB. Molecular Cell 9, 625-636 (2002)
• Xiao, C., Shim, J-H., Kluppel, M., Zhang, S-M., Dong, C., Flavell, R.A., Fu, X-Y., Wrana, J. L., Hogan, B. L. M., and Ghosh S. Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes & Development 17, 2933-2949 (2003)
• Zhang, D., Zhang, G., Hayden, M. S., Greenblatt, M.S., Bussey, C., Flavell, R. A. and Ghosh, S. A novel Toll-like receptor that prevents infection of kidneys by uropathogenic bacteria.   Science 303, 1522-1526 (2004)
• Jimi, E., Aoki, K., Saito, H., D’Acquisto, F., May, M. J., Ichiro Nakamura, I., Sudo, T., Ohya, K., and Ghosh, S. Selective inhibition of NF-kB blocks osteoclastogenesis and prevents inflammatory bone destruction In Vivo.   Nature Medicine 10, 617-624 (2004)
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  Lee, K.-Y., D'Acquisto, F., Hayden, M. S., Shim, J.-H., and Ghosh, S. Protein Kinase PDK1 Nucleates T-cell Receptor-Induced Signaling Complex for NF-kB Activation, Science 308, 114-118(2005)
• Yarovinsky, F., Zhang, D., Andersen, J. F., Bannenberg, G. L., Serhan, C.N., Hayden, M.S., Hieny, S., Sutterwala, F., Flavell, R. A., Ghosh, S. and Sher, A. TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science 308, 1626-1629 (2005)
• Shim, J, H, Xiao, C, Paschal, A., Bailey, S. T., Rao, P., Hayden, M. S., Lee, K.Y., Bussey, C., Steckel, M., Tanaka, N., Akira, S., Yamada, G., Matsumoto, S. and Ghosh, S. TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo Genes & Development 19, 2668-2681 (2005)