Publications

Selected Recent Publications

• Pasare C, Medzhitov, R. Control of B-cell responses by Toll-like receptors. Nature, 17;438(7066):364-368, 2005.
• Barton GM, Kagan JC, Medzhitov, R.  Intracellular localization of Toll-like receptor 9 prevents recognition of self-DNA but facilitates access to viral DNA. Nat Immunol. Jan;7(1):49-56, 2006.
• Stetson DB, Medzhitov, R. Recognition of Cytosolic DNA Activates an IRF3-Dependent Innate Immune Response. Immunity. Jan;24(1):93-103, 2006.
• Blander, JM, Medzhitov, R. Toll-dependent selection of microbial antigens for presentation by dendritic cell. Nature. Apr 6;440(7085):808-812, 2006.
• Kagan JC, Medzhitov, R. Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell. Jun 2;125(5):943-955, 2006.
• Rakoff-Nahoum, S., Hao L., Medzhitov, R. Role of Toll-like Receptors in Spontaneous Commensal-Dependent Colitis. Immunity, Aug;25(2):319-329, 2006.
• Blander JM, Medzhitov, R. On regulation of phagosome maturation and antigen presentation. Nat Immunol. Oct;7(10):1029-1035, 2006.
• Foster SL, Hargreaves DC, Medzhitov, R. Gene-specific control of inflammation by TLR-induced chromatin modification. Nature. 21;447(7147):972-978, 2007.
• Rakoff-Nahoum S, Medzhitov, R. Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science. July 6;317(5834):124-127, 2007.
• Medzhitov, R. Recognition of microorganisms and activation of the immune response. Nature. Oct 18:449(7164):819-826, 2007.
• Horng T., Bezbradica JS., Medzhitov, R. NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway. Nat Immunol. Dec;8(12):1345-1352, 2007.
• Sokol CL, Barton GM, Farr AG, Medzhitov, R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol. 9(3):310-318, 2008.
• Unni, AM, Bondar T, Medzhitov, R. In Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance. Proc Natl Acad Sci U S A. 5;105(5):1686-1691, 2008.
• Kagan JC, Su T, Horng T, Chow A, Akira S, Medzhitov, R. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol. Apr;9(4):361-368, 2008.
• Brodsky I., Medzhitov, R. Reduced secretion of YopJ by Yersinia limits in vivo cell death but enhances bacterial virulence. PLoS Pathog. May 16;4(5) 2008.
• Medzhitov, R. Origin and physiological roles of inflammation. Nature. 4;454(7203):428-35, 2008.
• Stetson DB, Ko JS, Heidmann T, Medzhitov R. Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell. Aug 22;134(4):587-98, 2008.
• Rakoff-Nahoum S, Medzhitov, R. Toll-like receptors and cancer. Nat Rev Cancer. 2009 Jan;9(1):57-63.
• Palm NW, Medzhitov, R. Pattern recognition receptors and control of adaptive immunity. Immunol Rev. 2009 Jan;227(1):221-33.