Peter S. Aronson

C.N.H. Long Professor of Internal Medicine
Professor of Cellular & Molecular Physiology
Section of Nephrology

Research Interests

Physiology and Pathophysiology of Urinary Electrolyte Excretion

Our general goal is to characterize the mechanisms regulating sodium, acid-base, and anion excretion by the kidney. Our work is primarily focused on membrane transport proteins mediating ion exchange, namely NHE isoforms mediating Na+-H+ exchange, and SLC26 isoforms mediating anion exchange. One approach involves the generation of isoform-specific polyclonal and monoclonal antibodies to identify the cellular and subcellular sites of expression of ion exchangers in the kidney and other tissues, and to study their biosynthesis and assembly into multimeric complexes. A complementary approach uses mice with targeted gene disruption to elucidate the physiological roles of ion exchangers and associated proteins under in vivo conditions. For example, recent work with mice lacking anion exchanger Slc26a6, which can function as an oxalate transporter, revealed a phenotype of calcium oxalate kidney stones. This finding in turn has motivated a search for SLC26A6 gene variants that might predispose to kidney stones in human patients.

PubMed Search for articles by faculty member

Selected Recent Publications

• Kocinsky, H.S., Girardi, A.C., Biemesderfer, D., Nguyen, T., Mentone, S., Orlowski, J., and Aronson, P.S. Use of phosphospecific antibodies to determine the phosphorylation of endogenous Na+-H+ Exchanger NHE3 at PKA consensus sites. Am. J. Physiol. 289: F249-F258, 2005.
• Thomson, R.B., Wang, T., Thomson, B.R., Tarrats, L., Girardi, A., Mentone, S., Soleimani, M., Kocher, O., and Aronson, P.S. Role of PDZK1 in membrane expression of renal brush border ion exchangers. Proc. Natl. Acad. Sci. USA 102:13331-13336, 2005.
• Dudas, P.L., Mentone, S., Greineder, C.F., Biemesderfer, D., and Aronson, P.S. Immunolocalization of anion transporter Slc26a7 in mouse kidney. Am. J. Physiol. 290:F937-F945, 2006.
• Jiang, Z., Asplin, J.R., Evan, A.P., Rajendran, V.M., Velazquez, H., Nottoli, T.P., Binder, H.J., and Aronson, P.S. Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6. Nat. Genet. 38:474-478, 2006.
• Knauf, F., Mohebbi, N., Teichert, C.,Herold, D., Rogina, B., Helfand, S., Gollasch, M., Luft, F.C., and Aronson, P.S. The life-extending gene Indy encodes an exchanger for Krebs-cycle intermediates. Biochem. J. 397:25-29, 2006.
• Hassan, H.A., Mentone, S., Karniski, L.P., Rajendran, V.M., and Aronson, P.S. Regulation of anion exchanger Slc26a6 by protein kinase C. Am. J. Physiol. 292:C1485-C1492, 2007.
• Kocinsky, H.S., Dynia, D.W., Wang, T., and Aronson, P.S. NHE3 phosphorylation at serines 552 and 605 does not directly affect NHE3 activity. Am. J. Physiol. 293:F212-F218, 2007.
• Becker, A.M., Zhang, J., Goyal, S., Dwarakanath, V., Aronson, P.S., Moe, O.W., and Baum, M. Ontogeny of NHE8 in the rat proximal tubule. Am. J. Physiol. 293:F255-F261, 2007.
• Zhang, J., Bobulescu, I.A., Goyal, S., Aronson, P.S., Baum, M.G., and Moe, O.W. Characterization of Na+/H+ exchanger NHE8 in cultured renal epithelial cells. Am. J. Physiol. 293:F761-F766, 2007.
• Monico, C.G., Weinstein, A., Jiang, Z., Rohlinger, A.L., Cogal, A.G., Bjornson, B.B., Olson, J.B., Bergstralh, E.J., Milliner, D.S., and Aronson, P.S. Phenotypic and functional analysis of human SLC26A6 variants in patients with familial hyperoxaluria and calcium oxalate nephrolithiasis. Am. J. Kid. Dis., in press.

Education:	A.B., 1967, University of Rochester M.D., 1970, New York University
Training:	Resident: University of North Carolina Fellowships: NIH and Yale University

Contact

Campus Address
Section of Nephrology
Department of
Internal Medicine
Yale School of Medicine
P.O. Box 208029
New Haven, CT
06520–8029

E-mail
peter.aronson@yale.edu