Arthur E. Broadus

Ensign Professor of Internal Medicine
Section of Endocrinology & Metabolism

Clinical Interests

Dr. Broadus specializes in disorders of mineral metabolism. He is a member of the Yale Bone Center and of the Endocrine Society, American Society for Bone and Mineral Research, and American Society for Clinical Investigation.

Research Interests

The parathyroid hormone-related peptide (PTHrP) was initially discovered at Yale as the tumor product that is responsible for the humoral hypercalcemia that complicates many types of cancer. It is now known that the PTHrP gene is a member of a small gene family that includes parathyroid hormone (PTH) and that PTH and PTHrP share not only homologous sequences but a common receptor. Yet the functions of PTH and PTHrP are remarkably different. The PTHrP gene turns out to be widely expressed in both adult and fetal tissues, and all evidence to date indicates that PTHrP functions predominantly as an autocrine/paracrine regulatory molecule. In the adult, functions include the control of placental calcium transport, regulation of smooth muscle tone in accommodative smooth muscle structures such as the uterus, and participating in the regeneration of peripheral nerves. In the fetus as well as in postnatal development, PTHrP serves as a developmental regulatory molecule. Such functions include PTHrP control of the differentiation of the mammary epithelium, the development of endochondral bone, and the eruption of teeth. Most recently, we have found PTHrP in the insertion sites of tendons and ligaments into cortical bone (in which PTHrP may mediate the bone formation that tethers these insertions to bone) and in articular cartilage (in which, PTHrP appears to maintain the undifferentiated state of acticular chondrocytes and in so doing protect against the osteoarthritis).

• Chen X, CM Macica, BE Dreyer, VE Hammond, JR Hens, WM Philbrick, AE Broadus. Initial characterization of PTH-related protein gene-driven lacZ in the mouse. J Bone Mineral Research, 21: 113-123, 2006.
• Macica C, G Liang, K Lankford, AE Broadus. Induction of parathyroid hormone-related peptide following peripheral nerve injury: role as a modulator of Schwann cell phenotype. Glia, 53:637-48, 2006.
• Chen X, CM Macica, A Nasiri, S Judex, AE Broadus. Mechanical regulation of PTHrP expression in entheses. Bone 41(5):752-59, 2007.
• Broadus AE, CM Macica, X Chen. PTHrP functional domain is at the gates of endochondral bones. Ann NY Acad Sci 1116:65-81, 2007.
• Chen X, CM Macica, A Nasiri, AE Broadus. Regulation of articular chondrocyte proliferation and differentiation by Indian hedgehog and parathyroid hormone-related protein. Arthritis & Rheum 58:3788-97, 2008.

A list of Dr. Broadus’ publications is available via COS.

Contact

Campus Address
Department of Internal Medicine
Section of Endocrinology
Yale University
School of Medicine
Box 208020
New Haven, CT
06520-8020

E-mail
arthur.broadus@yale.edu

Office Phone
203.785.3966

Fax
203.737.4360