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7156: Acyclovir Sensitivity Testing, Rapid Assay |
Synonym:
HSV Susceptibility to Acyclovir, Rapid Assay
Methodology:
Plaque Reduction Assay
Schedule:
On request
Reported:
3-10 days
Laboratory:
Virology
Additional Information:
YNHH Virology Guide PDF
SPECIMEN REQUIREMENTS
Collection Requirements:
HSV isolate in cell culture is required before susceptibility testing can be done.
Reference Range Comment:
Sensitive: <10% of HSV plaques remain in presence of 3 mcg/mL ACV
Reflexive Testing Criteria:
ID50 assay performed only on HSV isolates that are indeterminate by rapid acyclovir assay.
Clinical Indication Criteria:
Patient must have failed intravenous therapy.
Additional Notes:
Lack of response may be seen with oral acyclovir due to poor absorption of drug, suboptimal dosing or poor compliance. Therefore, a course of intravenous therapy is recommended before drug resistance is assumed.
CPT Codes:
87186, 87252
Manual Release Date:
10/16/2009
Format Date:
11/02/2009