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7164: Acyclovir Sensitivity Testing, ID50 |
Synonym:
HSV Susceptibility to Acyclovir, ID50
Methodology:
Plaque Reduction Assay
Schedule:
On request
Reported:
1 - 2 weeks
Laboratory:
Virology
Additional Information:
YNHH Virology Guide PDF
SPECIMEN REQUIREMENTS
Collection Requirements:
HSV isolate in cell culture is required before susceptibility testing can be done.
Reference Range Comment:
Sensitive to acyclovir: IC50 <= 2 µg/mL
Resistant to acyclovir: IC50 > 2 µg/mL
Reflexive Testing Criteria:
ID50 performed on HSV isolates that are indeterminate by rapid acyclovir assay.
Clinical Indication Criteria:
Patient must have failed intravenous therapy.
Additional Notes:
Lack of response may be seen with oral acyclovir therapy due to poor absorption of drug, suboptimal dosing or poor compliance. Therefore, a course of intravenous therapy is recommended before drug resistance is assumed.
CPT Codes:
87186, 87252
Manual Release Date:
10/16/2009
Format Date:
11/02/2009