Judy H. Cho, M.D.

Judy H. Cho, M.D.
Associate Professor of Medicine and Genetics
Director, IBD Center

B.S., 1979: Ohio State University
M.D. 1986: Ohio State University

Research Interests

Pathophysiology and treatment of inflammatory bowel disease (IBD). Genome-wide association studies have demonstrated that alterations in intracellular processing of bacteria (NOD2) and interleukin 23 pathway (IL23R) function are central to IBD pathogenesis.

Representative Publications

Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen F, Ramos R, Britton H, Moran T,
Karaliuskas R, Duerr RH, Ackhar JP, Brant SR, Bayless TM, Kirschner BS, Hanauer SB, Nuñez G and Cho JH. A frameshift mutation in Nod2 associated with susceptibility to Crohn's disease. Nature 2001; 6837: 603-606.

Gewirtz AT, Vijay-Kumar M, Brant SR, Duerr RH, Nicolae DL, Cho JH. Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease. Am J Physiol Gastrointest Liver Physiol. 2006; 290: G1157-1163.

Rioux JD, Xavier R, Taylor KD, Goyette P, Green T, Huett A, Kuballa P, Mei L, Regueiro M, Rotter JI, Steinhart H, Schumm LP, Barmada MM, Shugart YY, Nicolae DL, Silverberg MS, Cho JH, Daly MJ, Brant SR. Identification of novel susceptibility genes for Crohn's disease implicates a crucial role for autophagy. Nature Genetics 2006 39:596-604.

Abraham C and Cho JH. Clinical Implications of Basic Research: Bugging of intestinal mucosa. New England Journal of Medicine 2007; 157: 708-710

Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Griffiths A, Dassopoulos T, Bitton A, Yang H, Targan S, Datta LW, Kistner EO, Schumm LP, Lee A, Gregersen PK, Barmada MM, Rotter JI, Nicolae DL, Cho JH. A genomewide association study identified IL23R as an inflammatory bowel disease gene. Science 2006; 314: 1461-3.


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