The overall goals of my research are to characterize bone marrow derived stem and progenitor cells, and to define the molecular mechanisms that regulate the self-renewal and differentiation of these cells. Projects are focused on hematopoietic differentiation from hematopoietic stem cells in mice and humans, and on epithelial differentiation from as yet unidentified marrow cells. Our work on hematopoiesis is providing insights not only into normal blood cell development, but also to the pathogenesis of myeloid leukemia. Our work on epithelial engraftment, which is also referred to adult stem cell plasticity, is focused on the mechanisms of repair in response to tissue injury and disease.

Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, Neutzel S, Sharkis SJ. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105:369-377, 2001.

Grove JE, Lutzko C, Priller J, Henegariu O, Theise ND, Kohn DB, Krause DS. Marrow-derived cells as vehicles for delivery of gene-therapy to pulmonary epithelium, American Journal of Respiratory Cell and Molecular Biology 27:645-651, 2002.

Herzog EL, Chai L, Krause DS. Plasticity of marrow-derived stem cells. Blood 102: 3483-3493, 2003.

Harris RG, Herzog EL, Bruscia EM, Grove JE, Van Arnam JS, Krause DS. Lack of a Fusion Requirement for Development of Bone Marrow Derived Epithelia. Science 305:90-93, 2004.

Borue X, Lee S, Grove JE, Herzog EL, Harris R, Diflo T, Glusac E, Hyman K, Theise N, Krause DS. Bone marrow derived stem cells are recruited to wounded skin, and contribute to epithelial engraftment during healing. Am. Journal of Pathology 165: 1767-72, 2004.

Guo J. Schedl A, Krause DS. Bone marrow transplantation can attenuate the progression of mesangial sclerosis. Stem Cells, 2005.