My laboratory is interested in the molecular regulation of autoimmunity and lymphoid organ development, particularly endothelium, especially through the mediation of cytokines of the lymphotoxin/tumor necrosis factor (LT/TNF) family.

Drayton, D.L., Ying, Y., Lee, J., Lesslauer, W., and Ruddle, N.H., Ectopic LTab directs lymphoid organ neogenesis with concomitant expression of peripheral node addressin and a HEV-restricted sulfotransferase J. Exp Med 197: 1153-63, 2003

Oliver A.R., Lyon G.M., Ruddle N.H., Rat and human myelin oligodendrocyte glycoproteins induce experimental autoimmune encephalomyelitis by different mechanisms in C57BL/6 mice. J. Immunol. 171: 462-468, 2003

Soderberg, K.A., Linehan, M.M., Ruddle, N.H., and A. Iwasaki. MAdCAM-1 expressing sacral lymph node in the lymphotoxin- b deficient mouse provides a site for immune generation following vaginal herpes simplex virus-2 infection. J. Immunol. 173:1908-1913, 2004.

Drayton, D.L., Bonizzi, G., Ying, X., Liao, S., Karin, M., and N.H. Ruddle. IKK a kinase activity controls chemokine and high endothelial venule gene expression in lymph nodes and nasal associated lymphoid tissue. J. Immunol. In press, 2004.