The primary objective of Dr. Shulman’s laboratory
is to elucidate the cellular and molecular mechanisms responsible
for insulin resistance in liver and muscle in patients with type 2
diabetes mellitus. Recent studies by the Shulman group have
demonstrated that alterations in muscle mitochondrial metabolism (
Science 300;1140-1142, 2003, N. Eng. J. Med 664-671, 2004, Science
2005:307;384-387) may be responsible for lipid accumulation in muscle
and liver resulting in insulin resistance in these organs. Available
rotation projects for prospective MSTP students which address this
theme include (but are not limited to): 1) In vivo and in vitro NMR
studies of muscle and liver mitochondrial metabolism in humans and
various transgenic and knockout mouse models of type 2 diabetes, 2)
molecular and in vivo studies examining the regulation of mitochondrial
biogenesis in AMPK, PGC-1 and CaMIV transgenic and knockout mice,
3) In vivo and in vitro regulation of insulin signaling by fatty acids.
Rotation projects: please contact Debbie Mento (ext 5-5447) Or Dr.
Shulman. Lab Meeting Dates- Every Wednesday at 3:00 (if you would
like to attend) |
Kim JK, Kim YJ, Fillmore JJ, Chen Y, Moore I, Lee J,
Yuan M, Li ZW, Karin M, Perret P, Shoelson SE, Shulman GI.
Prevention of fat-induced insulin resistance by salicylate. J Clin
Invest. 2001 Aug 1;108(3):437-446.
Fernandez AM, Kim JK, Yakar S, Dupont J, Hernandez-Sanchez C, Castle
AL, Filmore J, Shulman GI, Le Roith D. Functional inactivation
of the IGF-I and insulin receptors in skeletal muscle causes type
2 diabetes. Genes Dev. 2001 Aug 1;15(15):1926-34.
Zhang CY, Baffy G, Perret P, Krauss S, Peroni O,
Grujic D, Hagen T, Vidal-Puig AJ, Boss O, Kim YB, Zheng XX, Wheeler
MB, Shulman GI, Chan CB, Lowell BB. OMIM Uncoupling protein-2
negatively regulates insulin secretion and is a major link between obesity,
beta cell dysfunction, and type 2 diabetes. Cell. 2001 Jun 15;105(6):745-55. |
