The long standing objective of research in this laboratory is to understand the cellular events and molecular mechanisms that govern development of the mammalian central nervous system. One line of investigation focuses on the fundamental issue of the regulation of cell proliferation and death (apoptosis) that determine the number of neurons allocated to the building of the cerebral cortex. The other series of studies concern molecular mechanisms involved in neuronal migration including cell-cell recognition, neuron glia-interaction and nuclear translocation. Yale press release for recent Kavli Prize in Neuroscience