Department of Psychiatry Faculty

Education

1983, B.A., University of California, Los Angeles
1988, M.D., Yale University

Certification:
1993, Diplomat in Psychiatry, #38212
1995, Diplomat in Child and Adolescent Psychiatry, #3943

Research Interest

Our group uses functional magnetic resonance imaging and cognitive activation paradigms to study brain functional sequelae of substance use in adolescents. Our recent work has focused on sequelae associated with use of nicotine, cannabis and methylenedioxymethamphetamine (MDMA). We employ longitudinal study designs to examine the relationship between changes in brain function and psychosocial and cognitive outcome and treatment response.

Recent Publications

Jacobsen LK, Slotkin TA, Westerveld M, Mencl WE, Pugh KR: Visuospatial memory deficits emerging during nicotine withdrawal in adolescents with prenatal exposure to active maternal smoking, Neuropsychopharmacology, 2005, published online.

Jacobsen LK, Krystal JH, Mencl WE, Westerveld M, Frost SJ, Pugh KR: Effects of smoking and smoking abstinence on cognition in adolescent tobacco smokers, Biological Psychiatry, 2005, 57:56-66.

Jacobsen LK, Mencl WE, Pugh KR, Skudlarski P, Krystal JK: Preliminary evidence of hippocampal dysfunction in adolescent MDMA ("ecstasy") users: possible relationship to neurotoxic effects, Psychopharmacology, 2004, 173:383-390.

Jacobsen LK, Mencl WE, Westerveld M, Pugh KR: Impact of cannabis use on brain function in adolescents, Ann N Y Acad Sci, 2004, 1021:384-390.

Jacobsen LK, D'Souza DC, Mencl WE, Pugh KR, Skudlarski P, Krystal JH: Nicotine effects on brain function and functional connectivity in schizophrenia, Biological Psychiatry, 2004, 55:850-858.

Jacobsen LK, Gore JC, Skudlarski P, Lacadie CM, Jatlow P, Krystal JH: Impact of intravenous nicotine on BOLD signal response to photic stimulation, Magnetic Resonance Imaging, 2002; 20:141-145.

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