Department of Psychiatry Faculty

Arthur Margolin, PhD Research Scientist Welch Center 495 Congress Ave. New Haven, CT 06519 Tel: 203-781-4690, x248 Fax: 203-781-4606Email: Arthur.Margolin@Yale.edu

Education:

B.A., 1972, New York University
Ph.D., 1983, Princeton University

Research Interest

The primary focus of my research team is the development and evaluation of treatments for cocaine addiction, including pharmacotherapies, behavioral interventions, and "alternative" therapies. In 1992, we established an acupuncture research program at Yale's Substance Abuse Center with the aim of conducting rigorous research into this widely used, but untested, treatment modality. Our research team has subsequently conducted a number of foundational studies in this area, including development of appropriate control conditions, as well as determining relevant outcome measures. Controlled clinical research of acupuncture has included a NIDA-funded, randomized clinical trial of acupuncture for the treatment of cocaine addiction, and participation in the multi-site Cocaine Alternative Treatments Study, which was based on methodology developed at our site. More recently, my colleague, Dr. Avants, and I have been investigating spirituality-focused interventions for the treatment of addiction and HIV risk reduction. As part of a NIDA Stage I behavioral development project, we have developed a manual-guided spirituality-focused intervention -- Spiritual Self-schema (3-S) therapy -- and have evaluated it in preliminary as well as a controlled studies. The intervention has shown efficacy in reducing HIV risk behavior, and is being further evaluated in residential and other settings. A group-level intervention for decreasing HIV risk for drug abusers developed at our unit is the Holistic Health Recovery Program (HHRP), which has shown efficacy in two randomized clinical trials, in populations of both HIV-negative and HIV-positive methadone-maintained patients. HHRP is now being disseminated nation-wide as part of the Diffusion of Effective Behavioral Interventions (DEBI) project funded by the Centers for Disease Control and Prevention.

Publications of Note:

Margolin, A., Kosten, T.R., Avants, S.K., Wilkins, J., Ling, W., Beckson, M., Arndt, I.O., Cornish, J., Ascher, J.A., Li, S.H., & Bridge, P. (1995). A multicenter trial of bupropion for cocaine dependence in methadone-maintained patients. Drug and Alcohol Dependence, 40, 125-131.

Avants, S.K., Margolin, A., Kosten, T.R., Rounsaville, B.J., & Schottenfeld, R.S. (1998). When is less treatment better? The role of social anxiety on matching methadone patients to psychosocial treatments. Journal of Consulting and Clinical Psychology, 66(6), 924-931

Margolin, A., Avants, S.K., & Kleber, H.D. (1998). Issues investigating complementary therapies in randomized controlled trials. Journal of the American Medical Association, 260(18), 1626-1628.

Margolin, A. Avants, S.K., Setaro, J.F., Rinder, H.M., & Grupp L. (2000). Cocaine, HIV, and their cardiovascular effects: Is there a role for ACE-inhibitor therapy. Drug & Alcohol Dependence, 61, 35-45.

Margolin A, Kleber HD, Avants SK, et al. (2002) Acupuncture for the treatment of cocaine addiction. A randomized controlled trial. Journal of the American Medical Association. 287(1) 55-63.

Margolin A, Avants SK, Warburton LA, Hawkins KA. (2002). Factors affecting cognitive functioning in a sample of HIV-seropositive injection drug users. AIDS Patient Care and STDs, 16(6), 255-267.

Margolin A, Avants SK, Warburton LA, Hawkins KA, Shi J. A randomized clinical trial of a manual-guided risk reduction intervention for HIV-positive injection drug users (2003). Health Psychology, 22(2), 223-228.

Avants, S. K., Marcotte, D., Arnold, R. M., & Margolin, A. (2003). Spiritual beliefs, world assumptions, and HIV risk behavior among heroin and cocaine users. Psychology of Addictive Behaviors, 17(2), 159–162.

Margolin, A. (2003). Acupuncture for substance abuse. Clinical Psychiatry Reports, 5, 333-339.

Avants, S.K., Margolin, A., Usubiaga, M.H., & Doebrick, C. (2004). Targeting HIV-related outcomes with intravenous drug users maintained on methadone: A randomized clinical trial of a harm reduction group therapy. Journal of Substance Abuse Treatment, 26, 67-78.

Avants, SK & Margolin, A. (2004). Development of Spiritual Self-Schema Therapy for the treatment of addictive and HIV risk behavior: A convergence of cognitive and Buddhist psychology. Journal of Psychotherapy Integration, 14(3), 253-289.

Avants, S.K., Beitel, M., & Margolin, A. (2005). Making the shift from ‘addict self’ to ‘spiritual self’: Results from a Stage I study of Spiritual Self-Schema (3-S) therapy for the treatment of addiction and HIV risk behavior. Mental Health, Religion, and Culture, 8(3), 167-177.

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