Department of Psychiatry Faculty

David Russell, M.D., Ph.D Assistant Professor of Neurology and Psychiatry 34 Park Street Tel: 203-974-7779 or 7675 Fax: 203-974-7686 Email: david.russell@yale.edu

Education

1991, M.D., Ph.D., Cornell University Medical College and the Sloan-Kettering Institute, New York, NY

Research Interest

My laboratory studies the role of neurotrophic growth factors in diseases of the adult brain and the mechanisms by which they act. Alterations in these factors and their intracellular signaling pathways may play an important role in the changes seen in midbrain dopaminergic systems in drug addiction and drug-induced movement abnormalities. Our studies have focused on a particular class of neurotrophic factors, the neurotrophins, and their receptors, called Trks. Other factors that modulate dopaminergic neurons are also under investigation in the brain and in vitro systems.

Laboratory Personnel

Teige Sheehan, Ph.D., postdoctoral fellow
Harold Schultz, Research Technician

Achievements and Honors

• 1981: Phi Beta Kappa
• 1982: BA with Honors in Biology, Oberlin College and Sigma Xi
• 1987: Julian R. Rachele Award for Outstanding Research Paper
• 1994: Administrative Chief Resident, Neurology

Publications of Note

Russell, D.S. (1995) "Neurotrophins: Mechanisms of action," The Neuroscientist, 1:3-6

Russell, D.S. (1995) "Neurotrophins: New players, clinical uses?" The Neuroscientist, 1:119-122

Widnell, K.L., Russell, D.S., and Nestler, E.J., (1994) "Regulation of cAMPresponse element binding protein (CREB) expression in the locus coeruleus in vivo and in a LC-like cell line in vitro." Proc. Natl. Acad. Sci USA, 91:10947-10951.

Berhow, M.T., Russell, D.S., Terwilliger, R.S., Beitner-Johnson, D., Self, D.W., Lindsay, R.M., and Nestler, E.J., (1995) "Influence of neurotrophic factors on morphine- and cocaine-induced biochemical changes in the mesolimbic dopamine system." Neuroscience, 68:969-979

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