Department of Psychiatry Faculty

Education:

B.A., 1969, Harvard College
M.D., 1973, Albert Einstein College of Medicine

Research Interests:

• Contribute to the development of a more physiologically based psychiatric nosology and therapeutics.
• Use fMRI, laboratory tests of cognition, and the induction of emotion to study aspects of normal brain function that exist at higher levels of functional organization than single cells or cell dyads and involve the integrated action of thousands of neurons.
• Use these same procedures to characterize the pathophysiology of major psychiatric illnesses.
• Develop computerized exercises that produce activity-dependent enhancement of neural processing to treat the cognitive deficits produced by psychiatric illnesses (cognitive remediation).
• Develop new theories of normal and abnormal brain function.

Publications of Note:

Books:

Wexler BE. Brain and Culture: Neurobiology, Ideology and Social Change. MIT Press, Cambridge, 2006.

Research Articles:

Wexler BE: A model of brain function: Its implications for psychiatric research. British Journal of Psychiatry 1986, 148:357-362.

Wexler BE: Failure at task-specific regional brain activation: New conceptualization of a disease entity Journal of Neuropsychiatry and Clinical Neurosciences 1991, 3:94-98.

Wexler BE, Warrenburg S, Schwartz GE, Jamner LD: EMG and EEG responses to unconsciously processed emotion-evoking stimuli. Neuropsychologia 1992, 30:1065-1079.

Wexler BE: Beyond the Kraepelinean dichotomy. Biological Psychiatry 1992, 31:539-541.

Docherty NM , Sledge WH, Wexler BE: Affective reactivity of language in stable schizophrenic outpatients and their parents. Journal of Nervous and Mental Disease 1994, 182:313-318.

Wexler BE, Hawkins KA, Rounsaville B, Anderson M, Sernyak MJ, Green MF: Normal neurocognitive performance after extended practice in patients with schizophrenia. Schizophrenia Research 1997, 26: 173-180.

Wexler BE, Stevens, AA, Bowers, AA, Sernyak MJ, Goldman-Rakic PS: Word and tone working memory deficits in schizophrenia. Archives of General Psychiatry 1998, 55:1093-1096.

Stevens AA, Goldman-Rakic PS, Gore JC, Fulbright RK, Wexler BE: Cortical dysfunction in schizophrenia during auditory word and tone working memory revealed by functional MRI. Archives of General Psychiatry 1998, 55:1097-1103.

Bruder GE, Wexler BE, Stewart JE, Price LH, Quitkin F: Perceptual asymmetry differences between major depression with or without a comorbid anxiety disorder: A dichotic listening study. Journal of Abnormal Psychology, 1999, 108:233-239.

Wexler BE, Anderson M, Fulbright RK, Gore JC. Improved verbal working memory performance and normalization of task-related frontal lobe activation in schizophrenia following cognitive exercises. American Journal of Psychiatry, 2000, 157:1094-1097.

Wexler BE, Gottschalk CH, Fulbright RK, Prohovnik I, Lacadie CM, Rounsaville BJ, Gore JC. fMRI of cocaine craving. American Journal of Psychiatry, 2001,158:86-95.

Bell M, Bryson G, Tasamine Greig, PhD, Cheryl Corcoran, MD, Wexler BE. Neurocognitive enhancement therapy with work therapy: Effects on neuropsychological test performance. Archives of General Psychiatry, 2001, 58:763-768.

Wexler, BE, Bell MD. Cognitive Remediation and Vocational Rehabilitation for Schizophrenia. Schizophrenia Bulletin, 2005, 31(4):931-941.

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